S-Trityl-poly(ethylene glycol)-block-poly(L-lysine trifluoroacetate) is a
linear hydrophilic block copolymer which has a poly(L-lysine
trifluoroacetate) section and a trityl protected thiol functionalized PEG section. It is a
crystalline solid soluble in water. Upon derivatization of the
poly(L-lysine trifluoroacetate) part, it can self-assemble into particles
in aqueous solution with a hydrophobic poly(L-lysine) core and a
hydrophilic PEG shell. Applications for S-trityl-poly(ethylene
glycol)-block-poly(L-lysine trifluoroacetate) include the conjugation to
active molecules for improved activities, the layer-by-layer deposition
techniques, and the complexation with nucleic acids for gene expression.
The trityl group is easily cleavable using a TFA/Et3SiH (98:2 v/v) mixture.
Our S-trityl-poly(ethylene glycol)-block-poly(L-lysine trifluoroacetate)
has been purified by dialysis, sterile-filtered on 0.2um, lyophilized,
and stored under Ar.
